Use of Khats

The Use of Khats

Use

Khat leaves are chewed mainly for their psychostimulant and euphoric effects. It has traditionally been used to elevate mood and combat fatigue buy khat in usa . Khat is also believed to have antiobesity effects due to appetite suppression. However, there are no well-controlled clinical trials to support any of these uses khat for sale online .

Dosing

100 to 300 g of fresh leaves are chewed to form a bolus (called a “quid”) that is held against the cheek on one side of the mouth while swallowing its juice; a typical “khat session” lasts for 3 to 4 hours. A khat preparation was administered at a dose of 0.8 mg/kg of cathinone in a pharmacokinetic study. khat for sale online

Contraindications

Contraindications have not been identified. khat for sale online

Pregnancy/Lactation

Avoid use. Documented adverse effects.

Interactions

Khat chewing interferes with the absorption of amoxicillin and ampicillin buy khat in usa . Nicotine and caffeine increase the stimulant effects of khat khat for sale online .

Adverse Reactions

Constipation is among the most commonly experienced adverse reaction in khat users. Other serious adverse reactions include cardiovascular, CNS, endocrine, metabolic, GI, dental, cognitive buy khat drug , psychiatric, and respiratory effects khat for sale online .

Toxicology

Khat may cause oral and gastric cancer, cerebral hemorrhage, severe headache, myocardial infarction (MI), duodenal ulcers, hypertension, low-birth-weight infants, and a variety of other severe effects, including addiction and associated sequelae.

Botany

Khat is a natural stimulant native to East Africa and the Arabian Peninsula, with distribution in parts of the Middle East and on the island of Madagascar. It is a tall evergreen shrub (2.7 to 3.7 m in height) that grows best at high elevations (1,500 to 2,000 m above sea level). Its tender twigs and leaves are harvested almost year-round. White leaves are more rare and more expensive than red leaves. Freshly harvested khat has traditionally been wrapped in banana leaves to keep it moist during export to neighboring African countries.Patel 2015 khat for sale online 

Uses and Pharmacology

Leaves of khat are chewed fresh for their psychostimulant properties.Al’absi 2013 The acute psychostimulant effects of khat include enhanced mood and alertness, euphoria, increased flow of ideas while studying, feelings of optimism, elation, a general sense of well-being, enhanced concentration, friendliness, contentment, ability to think more clearly, confidence, and improved vigilance.Al’absi 2013, Berihu 2017, Bongard 2015, Nakajima 2016, Nakajima 2017, Patel 2015 Also similar to amphetamine, cathinone, the active ingredient in khat, suppresses appetite, which explains the belief that khat may have antiobesity  buy khat drug effects.Al’absi 2013, Alshagga 2016 It has been used to prevent fatigue, and is thought to improve memory and alleviate pain.Berihu 2017, Mihretu 2017 In placebo-controlled trials, khat was found to increase motor activity, euphoria, and a sense of excitement and activation.Al’absi 2013 khat for sale online

When chewing khat, cathinone is released within 15 to 45 minutes, with peak plasma levels of cathinone obtained 1.5 to 3.5 h after the onset of chewing. Cathinone is detectable in plasma for up to 24 hours after consumption.El-Sayed 2012

Khat - Wikipedia

Dosing

100 to 300 g of fresh leaves are chewed to form a bolus that is held in the buccal sulcus against the cheek of the mouth while swallowing the juice it produces; chewing sessions typically last 3 to 4 hours.Al-Maweri 2017Patel 2015 In Scotland, khat has been blended and filtered to be served as a drink called “Herbal Ecstasy.”Patel 2015

A single dose of 0.8 mg/kg of cathinone, corresponding to 54 to 71 g fresh khat leaves, was administered in a pharmacokinetic study examining the amphetamine-like stimulatory effects of khat.Widler 1994 buy khat tea 

Although khat is perceived to improve concentration and memory, studies show that chronic khat use is associated with impaired working memory and mental impairments. Although khat does not demonstrate effects on long-term memory, there is evidence of short-term memory discrepancy depending on the duration of exposure.Berihu 2017 In one study examining effects of khat on cognitive control functions, working memory performance and cognitive flexibility were impaired in khat users compared with nonusers.Colzato 2011 Chronic khat use is likely associated with dysfunction in the prefrontal cortex as well as reduced  buy khat drug dopamine levels in the buy khat drug striatum; dopamine plays an important role in cognitive flexibility and updating working memory.Colzato 2011

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